Metal complexes are scientifically known to be active and effective as antibacterial, antivirus and some antifungal etc. This project work is targeted at preparing complex from transition metals say; cobalt, cupper, zinc and nickel and organic ligands synthesised from pyridyl based schiff bases, one from 2-aminopyridine and benzaldehyde and second from 2-aminopyridine and 2,4-dihydroxylbenzaldehyde. The analysis and completion is based on thin-layer chromatography, column-chromatography and IR-spectral analysis.
TABLE OF CONTENT
Dedication………………………………………………… i
Content………………………………………………………ii
Acknowledgement…………………………………………….iii
Abstract…………………………………………………………iv
List of figures……………………………………………………v
List of tables……………………………………………………..vi
List of equations…………………………………………………vii
List of tables………………………………………………….. viii
CHAPTER ONE
LITERATURE REVIEW
Introduction
The chemistry of transition elements
Objectives of study
Complexes of transition elements
why metal complexes are coluored
the nature of chemical bonding in transition metal complexes
Effect of the complex constituents
Effect of ligands
Effect of metal ion
The coordination chemistry of metal used (Nickel)
The chemistry of Schiff Base (Imine)
The Biological importance and activity of Schiff Base
Ligand studied
Pyridyl based Schiff Base
1.10. Apllications and activities of Schiff base complexes
CHAPTER TWO
1.MATERIALS AND EQUIPMENT
2.1. REAGENTS
2.1.1. Ethanol
2.1.2. Benz aldehyde
2.1.3. 2, 4-dihydroxylbenzaldehyde
2.1.4. Methanol
2.1.5. Glacial acetic acid
2.1.6. Diethyl ether
2.1.7. n-hexane
2.1.8. 2-aminopyridine
2.1.9. Distilled Water
2.10. Dichloromethan
2.11. Nickel metal salt
2.12. Terpene oil
2.13. Silica gel
2.2.EQUIPMENT
2.2.1. Reflux setup
2.2.2. Distillation setup
2.2.3. TLC plate and its materials
2.2.4. UV machine
2.2.5. Trituration setup
2.2.6. Column chromatography setup
2.2.7 Chemical Balance
2.3. EXPERIMENTAL TECHNIQUES AND PROCEDURES
2.3.1. General cleanupof glass wares and other apparatus
2.3.2. Distillation of Benz aldehyde
2.3.3. Refluxing to prepare our Schiff base in without catalyst
2.3.4. Refluxing to prepare our Schiff base with catalyst
2.3.5. Concentration using rotary evaporator
2.3.6. Running of TLC check
2.3.7. Trituration of Schiff base produce from 2, 4-dihydroxyl benzaldehyde with diethylether and methanol in different setup
2.3.8. Purification with column chromatography
2.3.9. Refluxing of the Schiff base with the metal salt (copper nitrate)
CHAPTER THREE
3.1 RESULTS
3.1.1. Melting point results
3.1.2. FTIR results and analysis
CHAPTER FOUR
4.1 Discussion of result
4.2 Conclusion
4.3. References.
